Malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in ischemic stroke: a systematic review

Abstract Introduction The low blood flow in ischemic stroke reduces oxygen and glucose induces a series of reactions that produce free radicals. Free radicals can destroy cell membranes (lipid peroxidation) marked by the elevation malondialdehyde (MDA), damage deoxyribonucleic acid (DNA) showed 8-hydroxy-2’-deoxyguanosine (8-OHdG). This review aimed to assess conclude research-based study systematically analyze relationship MDA/8-OHdG stroke. Method Cochrane handbook for systematic reviews, guideline preferred reporting items meta-analysis (PRISMA), synthesis without (SWiM) reviews: was used as this review. Inclusion criteria were primary studies every design, articles published English around January 2000–December 2021, human subject. A literature search applied 15 electronic medical journals. authors assessed quality risk bias each included study. Results evaluated 374 found searching, 30 met review, then underwent assessment bias. Conclusion MDA has role oxidative stress biomarker, outcome predictor, mortality post-stroke cognitive impairment depression hand grip strength predictor stroke; while 8-OHdG